How use the uart(ttyS5)?

I want to connect GPS board(3.3v) to uart5.
I’m add overlays:
verbosity=1
bootlogo=false
disp_mode=1920x1080p60
overlay_prefix=sun50i-h616
overlays=uart2 uart5 spi-spidev
rootdev=UUID=f64a1bf8-9eaf-4ea7-a699-71dd553b9872
rootfstype=ext4
usbstoragequirks=0x2537:0x1066:u,0x2537:0x1068:u

rangepi@orangepizero2:~$ sudo setserial -g /dev/ttyS*
[sudo] password for orangepi:
/dev/ttyS0, UART: 16550A, Port: 0x0000, IRQ: 31
/dev/ttyS1, UART: unknown, Port: 0x0000, IRQ: 0
/dev/ttyS2, UART: 16550A, Port: 0x0000, IRQ: 32
/dev/ttyS3, UART: unknown, Port: 0x0000, IRQ: 0
/dev/ttyS4, UART: unknown, Port: 0x0000, IRQ: 0
/dev/ttyS5, UART: 16550A, Port: 0x0000, IRQ: 33

But nothing works, at the start, the GPS board flashes the LED sends data, then stops. If I connect to ttyS0 contacts with root rights, I can receive data, but not through ttyS5 contacts. What am I doing wrong? how do I connect ttyS5?